In 1932, two reporters investigate a gangster war, and a bizarre incident: a transcontinental train was hijacked by two gangs, who were then massacred by a monster aboard the train.

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In 1931, the "Flying Pussyfoot" train departs for New York on the Grand Punk Railroad, carrying a group of (mostly) unrelated passengers.

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In 1933, Eve Geonard searches for her missing brother Dallas. In 1930, an immortality elixir is lost by its alchemist owner. In 1931, the train is doubly hijacked.

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In 1931 Ladd Russo likes to talk... mostly about slaughtering. In 1932, Eve begins searching for Dallas. In 1930, Slizard Quates searches for his missing elixir.

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In 1931, Jacuzzi Splot decides to stop the hijacking... but finds something has started slaughtering a gang. In 1930, Firo Prochainezo is inducted into the Martillo Family at a party.

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In 1931, the Rail Tracer continues its murderous rampage. In 1930, Dallas becomes an Immortal.

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Where it all began. In 1711, a group of Immortal alchemists fight over the elixir due to its power, and its dreadful proviso (they must kill each other off).

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Isaac and Miria spread happiness around them: in 1930, they meet and comfort Eve and later Ennis; and in 1932 they meet and comfort Jacuzzi.

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In 1932, after the train ends its trip, assassin Claire Stanfield (aka the Rail Tracer), in love with passenger Chane Laforet, meets his adoptive family, the Gandors.

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In 1931, Ladd almost kills Immortal Czeslaw Meyer. In 1932, Dallas attacks the Immortal Gandor brothers. In 1930, Isaac and Miria steal the elixir and head to the Martillos' party.

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In 1930, Firo flirts with Ennis, while his boss Maiza meets his nemesis... Slizard, Ennis's master. In 1931, Claire and Ladd fight aboard the "Flying Pussyfoot".

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In 1931, Isaac and Miria fall off the train with Czeslaw, and Ladd jumps off to rescue his fiancée Lua. In 1930, Isaac and Miria attempt to save Maiza from Slizard.

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In 1930, Firo manages to slay Slizard and rescue Ennis. In 1931, Isaac and Miria adopt Czeslaw as their brother; Claire proposes to Chane. In 1932 Eve arranges to rescue Dallas.

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In 1931, an Immortal named Elmer watches Firo, Ennis and Maiza reunite with Isaac, Miria and Czeslaw; later he visits Chane's Immortal father, Huey.

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Ladd's friend Graham Specter kidnaps Chane, now a member of Jacuzzi's gang. The gang sets off to rescue her, with Claire in hot pursuit.

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The 1932 reporters from the beginning finally pronounce the Immortals' affair they're investigating as too complicated and convoluted to have a beginning, and probably without an ending.

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