Dr. Shutt begins to do surgery again although his future in psychiatry is uncertain. A "suicide doctor" tries to get the hospital transplant committee to use organs that were not harvested properly, and promises one to Austin's patient without her consent. Sarin gas is released in a bank threatening many lives including Hancock's, who risks his own to save others. Wilkes loses it after the incident on the heels of the previous shooting at his son's school, leading him to take a drastic step. Diane returns to work after her maternity leave.

Austin has to give a physical exam to a former astronaut scheduled to fly the space shuttle. An old friend of McNeil's arrives at Hope dying of pancreatic cancer. Shutt treats a young rabbinical student who attempted suicide.

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Dr. Waters has a fever and gets a visit from Alan, the Chicago Hope lawyer who was shot and killed. Camille returns and her and Aaron rekindle their romance, Dr. Geiger and Dr. Nyland also pay a visit. A man has multiple surgeries while his disabled wife waits and Dr. McNeil gets an unexpected reward.

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Thanksgiving at Chicago Hope. Billy's mom shows up for Thanksgiving and goes into labour. A 13 year old Buddhist Llama is admitted under Dr. Yates with cardiac concerns and anxiety. Aaron has Thanksgiving with an actor who thinks he is Jesus.

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Jack gets bad news and has to return home. Billy's friend needs a new heart. Dr. Cacaci is peddling a line of home and beauty products. Jack and Lisa's relationship hits a crossroad.

Catera tries to get a terminally ill patient into a cancer test study. One of Shutt's patients confesses to murder. Cronk struggles with the decision to put his seriously ill dog to sleep.

An overweight patient makes Keith re-evaluate his own life choices. A visit from a former supervisor has Kate reliving their past relationship and re-evaluating her own relationships with others. Diane gets test results.

Parents facing a horrible situation want to gamble on future technology. Aaron's psych experiment goes horribly wrong. An Alzheimer's patient confuses Jack with someone from her past.

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A multiple birth has Chicago Hope hopping. Bobby and Diane help a very unusual patient. Aaron's dog needs therapy.

A man from Kate's past makes a brief but dramatic reappearance. A pregnant cancer patient faces an impossible choice. Dr. Cacaci makes a retaliatory allegation against Philip.

Mass casualties arrive from a rave. Among them are drug overdoses, a young woman who was raped, and a young man who changes the course of Kate's life. Philip continues to refuse to participate in his own defense.

Jeffrey Geiger returns having bought controlling interest in the hospital and he fires Austin, Kronk, Yeats, Catera, and Hancock. They decide to pursue their options. Aaron consults with the new pediatric surgeon, Gina Simon about a new born baby. And a young surgeon who was hired by Austin before her dismissal arrives and Geiger puts her to work.