Bavarian architect Marco Lanski calls fiancée Eva Wigand's bluff when she threatens to dump him rather then come along to his parents in Montalcino, near Sienna. Then he meets and falls in love with more recently immigrated doctor Katharina Berger. Her priority is getting biological father Volker Scheffler, a German actor she never gave a chance, to donate bone marrow for their leukemia-suffering pre-teen daughter Anja. Marco offers to help out financially, but Eva sabotages that by pretending to be abandoned pregnant with his inexistent child.

Dr. Stefan Weber accepts another temporary foreign 'holdiay doctor' posting in Tessin (Ticino, Italian Switserland) while regular compatriot Dr. Anne Schäfer goes visit her ailing mother Elisabeth Gruber. Only at his arrival they realize that reunites schooldays first lovers, now without spouses. Groom Andreas Kerbel is found badly wounded in the mountains, his bride ignoring he didn't bail out. Anne's romantically frustrated daughter Lucy is jealous and fickle, her ex devises a clever revenge on the family.