Richmond Trinity has closed its doors, and now many of the staff have been shifted to James River, a rundown hospital in a low-income area. Things are made even worse when Christina and Bobbie have a run-in with the ER nursing supervisor. Tom gives up his administrative duties and dives into direct care.

Christina disagrees with the hospital's plan not to treat a heroin-addicted patient and takes her grievances to the ethics committee. An unexpected illness forces a mother to reveal a potentially life-changing secret to her adoptive son. Camille begins to build a relationship with hospital employee Marcus.

Tom and his friend Paul are critically injured in a car accident, leaving Tom to worry if his injuries will prevent him from ever operating again. Candy makes an unexpected return from her tour of duty in Afghanistan. A child is pressured to tell the truth about his grandmother in order to save her life, even if it means the she could wind up facing criminal charges.

A death row patient is admitted to James River for a life-saving surgery, placing the hospital and staff members in the middle of an ethical battle. Tom continues to struggle with injuries he sustained in a car accident, while Christina begins to wonder if she's ready to take their relationship to the next level.

Tom faces surgery for his injuries. Camille is affected by two twin sisters in need of kidney transplants. A sick child's wish to meet a professional basketball player doesn't live up to expectations when he gets a visit from a retired player.

A language barrier hinders the treatment of a pregnant woman from Afghanistan who has taken a fall potentially injuring her baby. Tom prepares to undergo surgery. And Christina catches Camille in a compromising position.

An old friend resurfaces and Christina is determined to help her despite the insurance company's refusal to cover her treatment. Tom's growing relationship with Erin rubs Christina the wrong way, just as tension and silence build at home between Christina and Camille

Isabel, concerned for the safety of her son in foster care, kidnaps him and disappears. And it's up to Christine and Detective Nick Renata to find her. Tom gets back into surgery, while Bobbie and Steve try to help the family of the woman who injured him. Ray finds out the truth about Candy, and Kelly has a run-in with Malia and Judy.

A volatile situation with Camille prompts Christine to seek help from Det. Nick Renata. Erin clashes with Christina over Tom's career path. Kelly tries to track down a grieving mother's camera. And a figure from Steve's past comes back to haunt him.

The hospital goes into crisis mode when a construction accident causes an explosion and jeopardizes the hospital's commission inspection. Dr. Marshall continues giving Ray a hard time over his feelings regarding Candy. And Bobbie and Steve come clean with each other about their pasts.