Wayne has set the shrink ray effects to only last two hours, but when Grandpa unknowingly swallows the family van along with Wayne, Diane, and Amy inside, it is up to Nick to find them and get them out of Grandpa before it is too late.

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Wayne becomes concerned about his family's safety and invents a security system for their protection. F.R.A.N., the Felon Repeller and Accident Neutralizer takes her duties very seriously and involves herself in every facet of the household. Diane is wary of the overprotective computer, not realizing that F.R.A.N. has developed a mind of her own. When Wayne decides to pull the plug, F.R.A.N. holds the Szalinskis under "house arrest." Wayne and his family try to stop F.R.A.N. before it's too late.

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Wayne invents something that could make your vision perfect so Nick tries it out and can see practically anything, even dead people. He befriends a "friendly" ghost who gets into Wayne's body and Nick realises that the ghost isn't all that good. So he along with Wayne attempt to get control of his body so they can get the ghost out.

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Amy is in love with her teacher and when she finds out that her dad has made a time machine, the Szalinski Time Hopper, she decides to go back to the 70s to meet her teacher, when he was 17. She goes back but to 1976 and after numerous attempts decides not to return. Nick tells his dad, who goes back in time to rescue her before she suffers the ill effects of temporal displacement. While Wayne is in the past, he runs into teenage Diane and he figures out how to make up for both a forgotten wedding anniversary and a Time Hopper problem.

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Wayne accidentally shrinks himself and his brother, Randy, who find themselves in little trouble when they are mistaken for McDonald's Happy Meal Toys and brought home to a young boy who happens to be a fan of Randy's television series "Randy Rude: The Science Dude".

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When Wayne invents a neuron nudger, Diane accidentally turns it on and swaps her brain with that of Bianca's cat. Bianca, Wayne's scheming coworker, switches Wayne's brain with Quark's so she can use Wayne's body to access his vault at work. Nick and Amy then try to switch Wayne, Diane, and Bianca's brain back to their correct bodies.

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While Wayne works on controlling the cloning of himself, one of his new selves takes his place at work, where Bianca becomes suspicious of his geniality. Wayne is down because his clone is doing better than the real him. She gives his clone a friendship bracelet that is a tracking device, she befriends the clone and then uses him to kidnap Wayne.

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Wayne's invention succeeds in finding gold - a pot of doubloons claimed by a leprechaun, who puts a curse on the Szalinskis until they hand it over.

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To return from a time trip to Colorado in 1864, the Szalinskis must help an alien recover his starship from a ruthless gang, who master the alien's weapons and defenses.

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Wayne's chemical to increase intelligence has different effects on the family, including mind reading and levitation, while their dog, Quark, is able to hypnotise people.

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Diane wants to get in touch with her teenage self so that she can understand what Amy and her new client, Howard, are going through. Wayne has invented a machine where you can see yourself in the past. When the electricity goes out, Diane is stuck as a teenager. Now Wayne must fix the machine and the family has to deal with Diane and her rebellious self.

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Wayne feels overwhelmed with the demands of work and his family so he invents something that will make him go from place to place in seconds. He sets the level on high and somehow travels at the speed of light. Jennings finds a copy of the invention and is travelling fast too and playing tricks on people. The two of them get stuck at hyperspeed and must use another Szalinski invention to slow their molecules.

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Wayne accidentally blows up the mayor's car in front of the mayor which upsets Diane, who wants to run for the school board, so he goes back in time to redo things. He accidentally goes back to the time of the barbarians. When Wayne comes back he accidentally brings the Barbarians with him but when he tries to send them back the machine is broken. The barbarians become involved in the school board race when they are convinced that Diane's rival is Loki, the Norse god of mischief.

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Diane is very nervous about her case against a tough lawyer so Wayne invents a thinky ring to help her retrieve her thoughts better. Unfortunately, she becomes a brain sucking vampire. Wayne finds out and goes after her to lure her home. Nick manages to get the ring off but this turns him into a brain sucking vampire. Diane figures things out and plots to fight Nick and get the ring off before he takes over the world.

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Wayne turns Amy's bicycle into a super speed mountain bike. Amy goes on a bike ride through the woods, crashes, twists her ankle and finds refuge in a cave. Amy meets Bigfoot and she names him George after Curious George. He saves her and takes Amy to her house. Now the family must get him back along with his wife, a Yeti.

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Since Diane is allergic to chocolate Wayne tries to remove the allergic compound from the chocolate, but accidentally creates a chocolate that makes people fall in love. Damon, Amy's best friend, has a crush on Amy and Nick tries to get Amy to eat the chocolate. When she finds out how the chocolates work, she tries to get her crush "the make out king" to eat it. Diane, Wayne, Tiara, and a mutated Dr. Jennings also eat the chocolates, so Nick has to find the antidote that will make everyone (relatively) normal again.

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Wayne reluctantly has to make a toy bear more high tech after sharing his feelings at Jentech West. He makes the bear smart and while downloading data onto the bear's computer chip, a virus named Legion is also downloaded onto the chip. Now the bear is bent on taking over the world and the family now must stop the bear before he can wreak havoc.

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Wayne makes gadgets for spies in Canada. Now they are on a mission to stop a missile from blowing up the moon as the situation becomes increasingly complicated. Diane acts as a spy to discover more information and ends up with a don who takes her as a call girl. She bravely shares bed with him while her daughter is tortured by thugs.

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The prospect of dissecting a frog is giving Nick nightmares so Wayne invents a dream machine that would go into Nick's dream. He kills the frog but is threatened never to come back into the dream world again. Amy, against her dad's wishes, goes in so she can annoy Nick, so now the family can't sleep or else they could die.

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Wayne, wanting to please Nick, invents a Refuse Ingesting Protozoa or RIP that can eat anything. Jennings, who is being tracked by an environmentalist, puts toxic waste in Wayne's invention. RIP infected Quark, Quark infected the mail-man and so on. Now Wayne and family must stop these garbage eating zombies and get them to Jentech West where there is a high security system.

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Wayne's Chameleonator makes people invisible. The Chameleonator was originally made to change the people's skin color, so they wouldn't need to use make-up anymore. A mole in the company is telling another company about the invention. Amy and Wayne must stop the mole and get his invention back from the company that took it.

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Ar'nox the alien returns. This time, he comes for a visit only to have his starship stolen again. The Szalinskis must help him to get the ship back from the so-called "Men in Black."

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