In 1977, after Billy Milligan is accused of multiple rapes near Ohio State University, experts question if he has multiple personality disorder.

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Billy's troubled youth comes into focus via interviews with his siblings and childhood friends. At trial, his lawyers mount an unusual defense.

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As Billy's celebrity rises, a new doctor disagrees with his diagnosis and alters his treatment. Later, Billy takes his care into his own hands.

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With the help of friends and family, Billy goes on the run, changing his identity and mixing with some of Hollywood's biggest names.

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