Space Ghost talks to Terry Jones and makes many references to the "Monty Python" series with Zorak. Lokar offers Moltar a job working for him.

Space Ghost fires Zorak and Moltar and replaces them with MOE 2000, a supercomputer which eventually goes mad with power and tries to take over the show.

Space Ghost is down in the dumps because he and his girlfriend, Miss Nesbitt, broke up. Not even guest Carrot Top can cheer him up.

Space Ghost interviews guitarist Jonathan Richman.

The studio is under attack and a "Please Stand By" card is on the screen for part of the episode while Sonny Sharrock guitar music plays. However, the attack is a ruse by Space Ghost, as he just felt like playing some Sonny Sharrock music. Hence, this episode is meant as a tribute to Sharrock, who passed away in 1994.

Space Ghost turns to experts for advice on supernatural phenomena such as the disappearance of his phantom cruiser keys.

An angry, nerdy twentysomething named Commander Andy (who still lives with his parents) keeps hijacking Space Ghost: Coast to Coast. He keeps trying to read a list of demands while Space Ghost tries to interview Wylie Gustafson and Bill Manspeaker.

During interviews with guests Susan Olsen and Elvira, Space Ghost keeps having to leave the studio for various reasons. Chad Ghostal, Space Ghost's identical twin brother (who can be differentiated by his beard) swoops in and flirts with the two guests and leaves before Space Ghost returns. Eventually, Space Ghost appears on the set and catches Chad red-handed. Space Ghost proceeds to battle Chad, but their mom gets on the phone and tells them to stop fighting. They apologize and Chad leaves. Soon after, yet another Space Ghost look-alike appears. Space Ghost takes ...

Moltar plans a surprise birthday party for Space Ghost, and invites The Council of Doom to help him out. However, Moltar's idea of a surprise party isn't to celebrate Space Ghost's birthday, but to kill him. Zorak and Moltar prepare while Space Ghost is delayed by a battle with a giant blue robot and trying to pick up a package in the post office. Later, Space Ghost arrives at the set and notices the drapes (which are housing The Council of Doom, who are waiting to attack Space Ghost) are bulkier than usual and blasts them.

Space Ghost interviews Matt Groening. Meanwhile, Moltar escapes and hitches a bus to Jacksonville.

Last week, on a very special Space Ghost: Coast to Coast, Moltar escaped the studio and got on a bus to Jacksonville. Back at the studio, Space Ghost hires Tansut as Moltar's replacement, but he does such a bad job that he fires him and demands to know where Moltar is. When Tansut spills the beans, Space Ghost teleports into the bus that Moltar is on and convinces him to return.

Former "Late Show with David Letterman" writers design this unabashed spoof of the late-night talk show.

Space Ghost presents a cook-off competition on the show between three top chefs: Emeril Lagasse, Nathalie Dupree, and Martin Yan. The Council of Doom (Lokar, Metallus, Tansut, Brak, and Black Widow) act as the judges, but in the end, Space Ghost declares it a three-way tie anyway and blasts all of the Council of Doom members.

Performance artist Laurie Anderson riles Space Ghost by revealing that she never watches television, then waxes conspiratorial about cyberspace.

This special live action episode is hosted by "Space Ghost Expert" James Kirkconnell, who showcases five reenactments of scenes from old Space Ghost: Coast to Coast episodes. Reenacments of scenes from "Hungry", "Girlie Show", "Bobcat", "Freak Show", and "Banjo" are acted out by the Ghost Planet Dinner Theater Ensemble of Doraville, Georgia.