A controlling millionaire publisher gives the hospital a large donation in exchange for Gonzo watching over his daughter who has a rare blood disorder that needs round-the-clock care and is smitten with Dr. Gates. Trapper must find a replacement for Starch who has gotten married and retired.

With Gonzo accused of sexual misconduct, the hospital faces a public relations nightmare.

When Gonzo learns that an old classmate has put her health and sanity at risk by following a strict diet which encourages the use of diuretics, he goes after the well-respected doctor who founded the diet.

Riverside comes under fire after he takes over one of Gonzo's patients who happens to be dating his father and she ends up almost dying from an allergic reaction to fluorine.

Gonzo and Trapper are unsure how to treat a college student who has gotten mysteriously sick while doing a research paper on satanic rituals.

When a cop who is found to be homosexual is shot at a gay rally, Gonzo believes that he may have been shot by someone on the force and may be in danger at the hospital.

Trapper and Gonzo go on a trip to a cabin which becomes an adventure when an earthquake hits and the woman staying at the cabin needs serious medical care. At the hospital, Riverside leads the evacuation when the earthquake hits.

Members of the staff are baffled when a Vietnamese woman, who had initially refused surgery, is mysteriously operated on overnight without anyone seeing it. Trapper recognizes a politician who checks in under a false name and is brought in by a younger woman that is not his wife.

A shy and clumsy nurse asks Trapper for advice on how to attract Gonzo. A woman who is obsessed with her appearance is reluctant to have a tumor in her face removed.

A noted con man believes that the hospital is trying to pull one over on him when he is told that he needs a life-saving operation and his girlfriend is pregnant.

Trapper's busy hospital schedule becomes even more hectic when family problems crowd in. Melanie arrives to inform him the their daughter Kim is planning to drop out of school.

Gonzo and Trapper try to track down the family of a 10-year old girl who was hit by a car and is exhibiting erratic behavior. The only leads they have are gang members with whom she was living with.

Trapper convinces the board to fill the position of diagnosing physician with a former war buddy who is a double amputee.

There is plenty of excitement at the hospital for the opening of the day care center. However, the excitement is short-lived when a child is injured in a fall and it is found out that the day care director was once in a mental institution.

Instead of using his spare time to study for his medical boards, Jackpot looks into a sight restoring operation for his blind girlfriend.

Hub Wendover arrives at San Francisco Memorial Hospital for treatment for his leg and to be close to his son, Gonzo. Trapper operates on Hub finding his body riddled with cancer. Gonzo and Hub have some issues to deal with. Gonzo can't help but love the Father that supposedly walked out when he was four years old.

Gonzo accidentally runs down a homeless deaf girl. Trapper has to contend with Dr. Wang from China. They share a history in North and South Korea.

Seventeen-year-old Dr. Elliot Schweitzer is a new intern at SFMH. He takes his work very seriously, pushing himself to the limit. Trapper tries to help him remember that there is more to medicine than science and books.