Jackie's marriage is strained, as is her relationship with O'Hara after the intervention; Akalitus warns the staff that nearby hospitals have closed down, straining the staff and resources; Zoey publicly confesses her affair with Lenny.

Eddie tells Jackie he can't keep lying to Kevin, whom he now considers a real friend. Akalitus announces that All Saints is vying for a visit from Michelle Obama and confides to Jackie that O'Hara is looking for work at another hospital. Coop tries to bury the hatchet with Sam. The rift between Jackie and O'Hara softens when Jackie tells her that she'll follow her to any hospital just to be near her. Kevin tells Jackie his buddy Eddie called and is out of a job and asks if she can put in a good word for him at All Saints.

Much to Jackie's surprise, Kevin's younger sister, Tunie, shows up in the girls' bedroom, freshly hungover and tragically heartbroken after being dumped by her pilot boyfriend. On their way to work, Jackie tells Eddie she thinks Kevin installed Tunie to monitor her in the wake of his intervention. Lenny prepares Zoey a romantic picnic lunch only to crack her tooth when she bites into a sandwich where he's hidden his house key. Zoey talks things over with God, who's set up a makeshift piano bar in the ambulance bay. At the hospital, a Jewish Orthodox husband fights ...

Jackie's back in the swing of things, having re-hidden her stash of pills in the basement and mended fences with O'Hara. Zoey's working her first double and Jackie worries about her burning out. Lou, an out-of-work salesman, comes into the hospital and wins everyone over. O'Hara accepts the title of ER chief, which sparks a competitive streak in Coop. Kevin invites Eddie to a backyard barbecue to celebrate his new job. When Jackie gets home, she sees empty closets and drawers and panics-did Kevin leave her? She finds out he went to an Al-Anon meeting and the drawers ...

Jackie is on edge after realizing the stash of pills she stole from Bill the epileptic drug dealer is quickly dwindling. With a head of steam, Jackie confronts Eddie about his recent text exchanges with Kevin's younger sister, Tunie. Eddie maintains that it's completely innocent, while making the point that Jackie has no leg to stand on. Coop remains determined to battle O'Hara for the ER Chief title, but suffers a huge emotional blow when his mothers announce they're divorcing. Lou, the down-on-his-luck salesman, returns to the ER much worse for the wear. Akalitus ...

As Jackie's supply of pills starts to dwindle, her strategies become more intense and secretive. At All Saints, the saints from the chapel are being removed and carted off by the diocese. Between this, the lack of pills, her spiraling lack of control, and the saints leaving the building, Jackie finds herself unable to even walk through her own front door at the end of the day.

Jackie soothes Grace's anxiety about the upcoming saint pageant. Kelly continues to win over the All Saints crew. Zoey connects with a twelve-year-old boy whose mother was brought in as a drug overdose. A Native American patient momentarily lifts Coop's depression. Jackie pockets a Fentynal delivery that was meant for Oncology. Kevin confronts Jackie with the dental floss/drug stash he found.

Jackie visits Bill at his diner only to find that he has no pills for her. While helping Akalitus, Thor helps her face a deeper fear. Two drunk high school girls arrive in the ER after one of them face plants on the sidewalk. Coop is attempting to throw away his childish things that have cluttered his office. Jackie needs to get to Immaculate Virgin to see Grace perform in the Saint Pageant.

With Jackie's drug hookup crushed under a truck, she's run out of pills. Eddie confronts Kelly about the missing Fentanyl patches. Kelly follows protocol to the letter. Coop sets his sights on an old girlfriend. Zoey assesses the seriousness of her relationship with Lenny. O'Hara finally settles down enough to purchase an apartment. Jackie finds what she needs on the walk home from work.

The Peytons meet with Grace's psychiatrist Dr. Bowen. When Jackie asks Eddie if he can fill Grace's scrip, he's cagey. Akalitus pulls Jackie off a case and tells her that she's putting her on probation. O'Hara and Jackie argue in front of the staff. Coop asks Akalitus if he can reserve the chapel for his wedding. Kevin promises to be home but doesn't make it back until after Jackie is asleep.

Kevin takes off to batting practice where he meets Eddie. Eddie is sure Kevin knows about him and Jackie. Jackie, still sober is trying to get through her probation. Coop has a hard time getting Eddie to agree to be his best man. Zoey throws a party for Nurses Appreciation Week. Kelly and Jackie tag team a trauma where Jackie is forced to confess her probation.

Akalitus is all over the staff: HR has mandated a urine sample from all the nurses. Jackie keeps dodging her. Coop's wedding is today and Jackie has forgotten to get the cake. Jackie is avoiding the inevitable conversation her husband is determined to have with her. Coop's bride stands him up at the altar. Akalitus finally gets Jackie to take a pee test just as Kevin arrives at the hospital.