Dorothy, Rose, and Blanche are three women who share a house in Miami, Florida. Dorothy's elderly mother, Sophia, unexpectedly moves in after her retirement home burns down, and Blanche accepts a proposal of marriage.

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When Dorothy's daughter Kate gets married, Dorothy must confront her ex-husband Stanley, who walked out on their 38 year marriage for a younger woman.

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Rose is afraid of sexual intimacy with her boyfriend, Arnie, because she feels she would be cheating on her late husband, Charlie.

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Blanche's sister, Virginia, with whom she has had a tense relationship for years, comes to visit. She reveals that she needs a kidney transplant to save her life.

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When Dorothy's doctor boyfriend makes a pass at Blanche, their friendship becomes threatened.

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Blanche's belligerent grandson David comes to visit.

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The girls' friendship is tested by a bowling tournament.

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Rose feels unsafe in her own house after a burglary.

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Blanche dates an aerobics instructor who is considerably younger than she is. Meanwhile, Rose's mother comes to visit and resents the way her daughter treats her.

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Sophia falls ill suddenly, and the other girls worry she may be having a heart attack.

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Stan returns to try and make amends with Dorothy.

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Dorothy's wealthy sister Gloria wants Sophia to move to California with her.

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Rose doesn't tell her friends that her boyfriend is a little person because she fears people will make fun of them.

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Dorothy's affair with a married co-worker meets with disapproval from her friends and her mother.

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After Rose's boyfriend Al dies of a heart attack in her bed, Rose fears that she is a death jinx in the bedroom because her beloved husband Charlie died of a heart attack in her bed as well. To make matters worse, after Rose tracks down Al's sister to notify her of his death, she comes to find that his "sister" is really in fact his wife!

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Rose goes over her last will and testament with her daughter, who is shocked when she learns what happened to her expected inheritance.

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Blanche is concerned about the flirtatious behavior of her niece, Lucy.

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Dorothy is afraid to have an operation for a benign growth on her foot.

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A wealthy widower with two young children asks Blanche to marry him.

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An adult education teacher offers Blanche a passing grade in his course if she sleeps with him.

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Dorothy, Rose, and Blanche all come down with the flu at the same time.

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Rose loses her job and has trouble finding another one.

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Rose's sister Lily must come to terms with the fact that she is blind and needs assistance.

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Blanche's father visits, telling that he has sold the family mansion to finance his dream to become a country music singer. Dorothy disputes with the girls' next-door neighbor over storm damage.

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The girls remember how they came to live together; Blanche put an ad for a room for rent on a grocery store bulletin board, and Rose and Dorothy answered it.

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