A blackout at Chastain creates tensions between the doctors.

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Conrad's father, the new chairman of the board, wants his input in his discussions about Chastain's expenses; a sharp and sophisticated medical device rep inserts herself into the doctors' work to promote her products.

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Nic and Conrad think about their history when they diagnose a husband and wife with mysterious symptoms.

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Chastain is flooded with concert goers following a stampede at a music festival grounds that leaves many in need of doctors.

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When Bell makes the executive call to utilize Julian Booth's medical devices, rather than the hospital's usual products, Kit and AJ must stop their momentary feuding in order to team up against him. Elsewhere in the hospital, Conrad and Nic work to make a child's dreams come true after finding out his cancer has returned and the rest of the staff takes notice of Julian and Devon's new friendship.

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Halloween at Chastain proves to be just as spooky as ever when Conrad is tasked with diagnosing a young woman admitted to the hospital with extreme night terrors. Meanwhile, Devon faces his first Halloween in the ER, Nic panics over her decision to bring her newly sober sister to Mina's epic annual Halloween party and Bell finds an interesting way to make use of his new assistant.

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When patients from the hospital's prescription drug trial start suffering life threatening side effects, Nic fears that her sister Jessie may be in danger. As a result, she and Conrad work to convince Bell that these trials are not worth the risk. Meanwhile, Mina, Austin and Kit must set aside their competitive nature and work together on a patient whose health is quickly deteriorating and Devon uses Julian as the beta tester for a product he's designed.

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Conrad goes head-to-head with Bell after he recommends one of Julian's risky medical devices to Zoey, who's already lost one son and is back in the hospital with the other. Nic fears that Conrad may be getting overly attached to his patient. Meanwhile, Mina and Austin grow closer while working on a difficult heart transplant, Devon embarks on a very difficult day and Dr. Lane Hunter returns.

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Devon's doubts about his relationship reach a peak as his friends and family gather for his big wedding day. As Chastain's leading medical device company, Quovadis, continues to succeed, Julian makes a discovery that leaves her uneasy about her involvement in it all. Meanwhile, Conrad continues to work on his relationship with Marshall and Bell takes a risky offer in order to make a mistake from his past disappear.

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Lane Hunter's victims and their families become outraged when she is released from prison. Bell, although responsible for posting Lane's bail and getting her released, continues to be tortured by her manipulation.

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When a medical device fails on a former Chastain employee, an investigation is opened up, which pits Dr. AJ Austin against Quovadis. As Mina and Bell work to get to the bottom of what went wrong, Devon distracts himself with another patient who's experiencing mysterious stomach pains. Meanwhile, Nic forms a bond with her new partner at the clinic and Conrad's relationship with the Barnett family continues to grow.

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When a nasty flu season turns out to be masking a terribly infectious disease, Chastain must race to quarantine and diagnose infected patients. While Conrad, Nic and Alec work tirelessly on Meg, who was Nic's favorite guard from her stint in prison, Devon and the others treat Sam, a love-sick patient with flu-like symptoms. Mina finds herself testing Quovadis medical devices in an effort to defend Dr. AJ Austin, who, feeling responsible for the death of a patient, is serving penance by staying away from the OR. Meanwhile, Conrad is prepared to take the next step with ...

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Conrad, Kitt, Mina and the Raptor work to save the life of a med student in need of a triple-organ transplant, drawing Bell back to the OR for one of the Chastain's riskiest surgeries yet. After the police find Julian's empty car in a nearby lake, Devon does some investigating of his own to find out what might have happened. Meanwhile, Mina and the Raptor hound Bell to halt his business with the risky medical device company, Quovadis, and Nic makes a rash decision regarding her sister.

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When Conrad's attempt to surprise Nic with a lavish Valentine's Day dinner is foiled, he gives the reservation away to someone who could really use it. Mina and Devon distract themselves from all Valentine's celebrations by trying to figure out how their seemingly healthy neighbor has suddenly passed away. Meanwhile, Kitt gives dating advice to a sex-injured patient, Irving hits a crossroads in his not-so-secret relationship with Nurse Jessica, and Bell decides to celebrate the day in the OR.

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Bell's confidence in Quovadis continues to waver when the poster child for one of its medical devices, Henry Barnett, is rushed back into the ER, experiencing seizure-like symptoms. Meanwhile, Mina's past comes to light when her mother, famous Nigerian surgeon Dr. Okeke, pays a visit to Chastain, and Conrad makes a risky move when Henry returns to the hospital.

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The surgeons are determined to shut down Quovadis after Henry Barnett almost loses his life due to a device malfunction. As Mina and Devon set out to find the truth, Bell, AJ and Conrad work to save the life of Chastain's favorite custodian, Simon. Meanwhile, one of Alec's old patients ends up in the ER, forcing him to question if he made the right choice to leave his old practice for Nic's clinic.

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The surgeons work together to save the life of the Raptor's old mentor, Abe, who is their only inside source to Quovadis. Unfortunately, when Nic and Conrad take on a patient needing the hospital's only viable ECMO machine, they must decide between saving the life of Abe or saving the life of their younger, more stable patient. Meanwhile, Marshall puts himself in serious danger to help take down Gordon Page once and for all.

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Chastain picks up the pieces after the fall out with the corrupt medical device company Quovadis, leaving Marshall ready to charter new territory in the medical field, and Devon to finally discover the truth about what happened to Julian Booth. As Conrad and Alec team up to help a young gymnast experiencing mysterious symptoms, Nic focuses on her sister, who's back with their estranged father, Kyle, in tow. Meanwhile, Bell rushes to Kitt's aid when her ex-husband comes to the ER needing emergency surgery.

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Während eines Blizzards muss Mina eine schwierige Operation durchführen, weil AJ in den Schneemassen steckengeblieben ist. Währenddessen kümmern sich Nic und Conrad um eine alte Dame, die kurz vor ihrem Tod steht.

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Nach einem ernsthaften Gespräch beschliessen Conrad und Nic, sich zu trennen. Kurz darauf wird Nic Zeugin eines schrecklichen Verbrechens. Devon steht einer Frau bei, die nach einem Kaiserschnitt Komplikationen hat. Den Oberarzt scheint das wenig zu kümmern und Devon glaubt zu wissen, warum.

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Es wird viel zu wenig Blut gespendet, dem Chastain fehlen Blutkonserven. Conrads Patient kann deshalb nicht operiert werden, weshalb er zu extremen Mitteln greift. Währenddessen versucht Nic alles, um ihrer Schwester zu helfen. Und AJ erhält wichtige Informationen über seine Vergangenheit.

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Nach einer Nacht in einem Club hat Mina eine Platzwunde am Kopf und eine Gedächtnislücke. Conrad versucht Nic davor zu bewahren, eine grosse Dummheit zu machen, während Dr. Bell alles unternimmt, um einen grosszügigen Spender fürs Chastain zu finden.

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Nic schafft es endlich, ihren Vater davon zu überzeugen, seine Niere für Jessie zu spenden. Doch dann treten bei der Operation unerwartete Komplikationen auf. Währenddessen bereitet AJ die Herzoperation an Minas Ex-Freund Micah vor.

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