Arnold must have an appendectomy. Fred Tanner wants his daughter Alice put in a bedroom away from Arnold. When the two learn of this, they run away.

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Arnold's life is put on the line when the kids find out they cannot share a hospital room and end up running away on the night before Arnold's surgery.

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At Arnold's suggestion, a TV producer gives Larry Alder an audition for a TV hosting job.

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Mrs. Garrett receives a marriage proposal from a younger man with whom she attends night school.

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Arnold wants to know where babies come from, but no one will give him a straight answer until one of the other tenants in the building, a woman whose pregnancy sparked Arnold's curiosity, complains to Mr. Drummond.

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Arnold wants to meet his hero, world champion boxer Muhammad Ali. Willis and Kimberly meet him and say that their little brother is dying and that his last wish is to meet him.

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Mr. Drummond's plans to officially adopt Arnold and Willis are delayed when a man claiming to be the boys' cousin claims he was promised custody in their father's will.

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While Mr. Drummond's lawyers investigate Jethro Simpson's claim, Arnold and Willis prepare themselves for the possibility that they may have to live with the man.

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Willis wants to beat an obnoxious braggart in an upcoming father and son athletic competition at the YMCA. Believing Mr. Drummond may not be able do it, he asks another man to be his "father".

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Mr. Drummond's old friend, Larry Alder, visits New York on a business trip to present a business plan for purchasing a television station.

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A girl at school pretends that she likes Arnold only so that she can get close to Willis.

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Arnold and Willis find an expensive watch in the hall of their building and then Willis is accused of stealing it from a neighbor's suite.

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Arnold saves a dog from being hit by a car, but when the dog bites him, Mr. Drummond thinks the dog might have rabies.

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While a new housekeeper, Adelaide Brubaker, takes over from Mrs. Garrett, Mr. Drummond decides to run for city council after a friend's suggestion.

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Mr. Drummond is lonely so Arnold and Willis set him up with a date from a computer dating service but do not know that Mr. Drummond's friend set him up with a date as well.

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Arnold and Willis apply for welfare when they think Mr. Drummond's company may be going under.

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Arnold and Willis go into business together selling Adelaide's homemade brownies.

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Arnold is tired of being bullied at school so he takes karate lessons.

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Arnold and Willis get trapped in the building's storage room and reminisce about time with the Drummonds.

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Mr. Drummond scolds Arnold for secretly recording other people's conversations. Arnold disobeys him and records Kimberly's boyfriend Roger making racist comments about Willis to his sister.

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Arnold's classmates accuse him of being a teacher's pet when their teacher, Miss Osbourne, goes out with Mr. Drummond.

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A huge fight ensues when Kimberly invites her friends from Eastland Academy over at the same time that Willis has his friends over.

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Arnold's beloved goldfish Abraham passes away.

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Willis joins a gang in spite of Mr. Drummond's warnings.

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