Peggy calls Mannix when her young black male friend and his wounded partner show up, as innocent bystanders from a deadly liquor store robbery.

A shady lawyer suspected of throwing Joe's friend from a high-rise, hires him to look for a woman he claims he nearly ran over during the time of the crime.

Jean McBride, an old flame of Joe Mannix' who still lives in his hometown of Summer Grove, appears in his office one evening. Jean is married to Troy McBride, who once quarterbacked the Summer Grove football team on which Mannix also played. But now a double-tragedy has befallen Troy -- he is in an iron lung as a result of an accident, and has also been charged with murder. Mannix accompanies him and Jean back to Summer Grove to assist in the defense of the murder charge -- but his return home also forces Mannix to deal with unresolved conflicts with his father, from ...

Mannix is hired to look into who's trying to kill a movie studio's popular, but non-believing, arrogant male star.

Benjamin Holland, a former physician, runs a general store in a small town up the coast from Los Angeles. Holland lost his medical license two years earlier when he reported the wrong lab results to a surgeon and then disappeared from the hospital without permission. Now he is being prosecuted for practicing medicine without a license because he administered life-saving treatment to a young boy. His girlfriend, a woman named Andrea, is an old friend of Joe Mannix from their college days, when she was "queen of the freshman ball." She believes that the solution to ...

Three thugs hold Mannix, Peggy, and a woman hostage, claiming they want the $312,000 she has in a briefcase at home, but they may be after something even more valuable.

A widow hires Mannix to try and prove murder when two scuba divers drown her husband and make it look like an accident.

Maggie Wells, the secretary of a private investigator who was murdered, is on her way to see Joe Mannix. The cab driver taking her there fails to follow the route to Mannix' office, and then attempts to shoot her, but she is able to escape. Shaken, she manages to meet with Mannix, and asks him to figure out why someone is trying to kill her. Mannix places her in a trailer in a secluded location, and tries to get her to remember as many details as she can about her late boss, in order to figure out which of his former clients' business dealings might have put her in ...

A husband is driving his wife home after their anniversary celebration when he apparently runs down a man on a darkened street. The couple returns to the scene but can find no evidence of the man they thought they hit. Reluctant to go to the police because the husband had been drinking that night, they hire Mannix to make sure that no one was injured. Mannix approaches the only witness to the incident posing as the driver of the vehicle, but the witness suddenly claims that he saw nothing. Then the mystery deepens as Mannix is visited by two men who accuse him of ...

Mannix is grazed by a bullet which causes his blindness indefinitely, and then he's conditioned by an ex-marine for a possible return of his would-be killer.

The president of a corporation reported lost at sea, secretly returns to Mannix claiming his small plane was sabotaged and to try to find out who tried to kill him.

Sun and Sky, the horse favored to win the Kentucky Derby and possibly the Triple Crown, is being shipped to Kentucky to participate in the upcoming race. During the flight, however, all four members of the cargo plane's crew are overcome by some kind of drug, though the pilot manages to radio a distress call before losing consciousness. Mannix is hired by the insurance company holding the policy on the missing horse to investigate what happened. His search turns up the missing plane, and all four unconscious men, but not Sun and Sky. Mannix discovers that at least two...

Peggy has an old friend named Eve Chancellor, whose husband Jim started on the police force at the same time as Peggy's late husband. Eve is concerned about her son Cap, who has dropped out of school and spends much of his time away from home without accounting for his activities. When he brings a gun home one day, Eve hires Mannix to find Cap and to learn what he is involved in, hoping to help Cap avoid straying into a life of crime.

Mannix investigates when police uncover evidence that suggest Peggy's police husband killed while stopping a burglary, was actually an accomplice.

Mannix is about to leave his office to meet a client one night when he receives a telephone call suggesting that he spend the night at home instead. As he exits his office, a shot is fired at him. Mannix manages to meet the client anyway, a secretive executive who claims that a blackmailer is threatening to reveal embarrassing information about his wife. But as the case grows more involved, Mannix' client suddenly denies having hired him, or even knowing who he is.

Against his better judgment, Mannix agrees to look into the case of a young man who twice robbed the same pharmacy seeking drugs. The second time, he shot one of the employees, but even though the police had the pharmacy staked out, he managed to escape. The accused man's wife hires Mannix, insisting that her husband was incapable of committing such a crime. Mannix initially finds little to encourage him, but as he delves into the background of the man who was shot, he finds that the police account of what supposedly happened doesn't add up.

In a story reminiscent of "Rashomon," Mannix is hired by publishing executive George Diamond to locate Diamond's secretary, Winifred Hill. Hill may -- or may not -- have seen Diamond attempt to push his estranged wife, Stella, into the ocean near his beach house. In a panic, Hill goes into hiding. Diamond claims that she misinterpreted what she saw and tells Mannix he simply wants Hill to know the truth. During the course of his investigation, however, Mannix uncovers several different versions of what happened, including two from George Diamond. Then a murder takes ...

Mannix is hired by a bank to search for Paul Gantry, an Australian sailor who stands to inherit a sizable sum of money. To find him, Mannix goes under cover at the waterfront posing as a sailor looking for any of his "shipmates" from a recently sunken freighter, the Harlequin, on which Gantry served as one of the crew. As Mannix learns more information about the case, however, he comes to have doubts about whether Gantry really stands to collect the inheritance as his client informed him.

Joe Mannix is invited to a party at the home of Phil Graves, with whom he served in the Army during the Korean War. Now Phil is a bank executive married to a wealthy socialite named Kathy. She confides in Joe that there have been three recent attempts on her life, including one that day when someone apparently tampered with the brakes of her car. Joe agrees to look into why someone would have tried to kill her, and pursues the identity of a mysterious "Sylvia," when he finds an expensive locket engraved with that name in Kathy Graves' car.

Three attempts are made on Mannix' life within a short period of time, and the killers were each offered a substantial sum of money to do the job. Mannix concludes that the only man who hated him enough to put out these contracts on his life was Frank Bauer, whom he captured and helped put in jail for a murder and robbery in Nevada. The only problem: Bauer, who had recently broken out of prison, was killed during his escape. Mannix decides to go to Nevada to find out whether Bauer's brother may be behind the attempts on his life -- and perhaps to find the more than ...

When Mannix tries to find out what a disturbed little girl knows about her murdered doctor and $150,000 in stolen bonds, they both become marked for assassination.

Peggy and her son are held hostage by men who want the evidence that Mannix has, that proves his detective friend was murdered.

A controversial television interviewer telephones a shadowy figure named Harry Armitage for the "hot seat" segment of his show, accusing Armitage of bribery and influence peddling. As he speaks to Armitage on live television, shots ring out and Armitage is later found dead in his apartment. A woman named Muriel Price is found running from the scene, and her gun is determined to be the murder weapon. Joe Mannix, who had just been hired by Armitage before his death, is then hired by Muriel's twin sister, Valerie, to try to prove that her sister is innocent.

A young woman who has entered a county fair competition in a rural community north of Los Angeles disappears, and her wealthy father hires Joe Mannix to look for her. As Mannix begins his investigation, everyone he interviews claims that the woman never arrived in town. Then everyone -- the police, the town council, and even his hotel clerk -- suddenly seem interested only in having Mannix leave town as quickly as possible. Mannix learns, however, that they are all frightened by an extortion plot that involves not only the missing woman, but a threat to every person ...

Mannix helps his carnival owner friend find out if any of the workers are causing accidents that might be attempts on her life.