Zsalynn is finally free of Gareth, her ex-husband who wouldn't let her lose weight; Christina faces a difficult challenge when she passes out at home.

Olivia strives to weigh-in under 200-lbs as she lives by herself for the first time and suffers an unexpected loss. Battling a series of let downs, James fights to reach his goal of skin surgery and to live a fulfilling relationship for the first time.

Away from Dr. Nowzaradan's care, Penny has returned to Maryland believing she can make the right choices to lose weight, but has she truly changed? Dating for the first time in her life, Tara continues to lose weight and is learning to balance new roles.

Chuck starts from scratch during his second year of weight-loss, discovering a promising new relationship. Paula juggles many responsibilities head at once, but is it too much to stay on track for her weight-loss goal?

At age 23, and over 600-lbs, Amber relies on her family, and boyfriend for even simple needs. Her fear of dying young is so overwhelming that she makes the decision to relocate 2,000 miles in hopes that weight loss surgery will give her life back.

Weighing in at over 600-lbs, 37 year old Susan is committed to drastic weight loss. But, when an unforeseen medical disorder strikes her mobility, finding the strength to make it through these obstacles is a matter of life and death.

At nearly 700 lbs., 51-year-old Pauline has an addiction to food that is killing her and taken over the life of her son, who is the primary caretaker. Can she overcome this addiction to change her lifestyle and save both their lives?

At just 24, Bettie Jo is eating her way towards 700-lbs. Housebound, she is reliant on her husband for even basic needs. Bettie Jo's future relies on her losing weight, and her husband losing his fear that if she loses weight, she will leave him.

At 42 years old, Angel is staring death in the face. She is struggling to make a positive change and be an active part of her partner and son's lives. With so much at stake, can she turn her life around?

Joe is only 30, and trapped in an 800-lb body. He lost his job and is mostly housebound. Can Joe find the strength to face his past and save his life?

Laura has used food to cope with her emotions for too long. Confined to a wheelchair, relying on an oxygen tank to breathe, she depends upon her husband and mother to survive. Love for her family must conquer her demons if she is to turn her life around.

Charity weighs nearly 800-lbs. Suffering from flesh-eating bacteria and butterfly shaped fat deposits; she is unable to function without help form her family. When unexpected bad news threatens her weight loss journey, she must decide if she can continue.

Chay is just 23, but to cope with the emotional turmoil of his childhood he has eaten his way to 600-lbs and it's threatening to kill him before turning 30. When Chay loses his emotional support, he must find new strength to take control of his life.

Marla is so heavy she cannot stand up. Bedridden, her true weight is unknown but estimated at 800-lbs. Marla must face the facts about her health and the toll it takes on her supportive family if she is to save her health.