After meeting and falling in love at a barriatric rehab center, Lee and Rena are battling health and anger issues while taking a desperate, second attempt to save their relationship and their lives.

A woman whose extreme obesity has left her nearly immobile must overcome both her physical and emotional pain if she is ever to live a normal life again.

A devoted girlfriend and loving aunt, Alicia is all smiles and laughter on the outside, but on the inside she is terrified that her addiction to food will kill her before she can marry her long-time love or watch her nieces grow up.

Liz is completely bed bound with severe lymphedema that makes it impossible to walk. Utterly isolated, with no friends, she battles depression, and lives with her mom who is too ill to take care of her. Liz desperately wants to become mobile.

Unable to stand for more than a short period of time, Karina's weight has placed a burden on her parents and driven a wedge between she and her sister. Can Karina lose weight and repair the damage to her family?

James "LB" Bonner spent his early life trying to prove himself to his adoptive family, but after losing a leg and battling obesity, LB must take a new path to save his health and his family relationships.

Lisa's struggle with her weight began as a child and significantly worsened after witnessing her brother's murder. Now bedridden and unable to care for herself, Lisa must find a way to lose the weight or she will never see her grandchildren grow up.

With the support of his fiance, Kathryn, Robert turns to Dr. Nowzaradan in a final, desperate attempt to save his life. He tries to reverse a lifelong food addiction that has left him bed-bound, saddled with grotesque lymphedema, and nearly 900-lbs.

After years of a tumultuous relationship with her husband, Tamy's eating addiction has caused her weight to balloon over 500-lbs. She has become a hermit after years of shame, and hopes to restart her life so she can better care for her son Zachary.

Fearing he'll suffer the same fate as 700-pound brother David, Benji hopes to be able to support both himself and his brother on their life-or-death weight loss journey.

A former plus-size model and "big is beautiful" advocate, Renee now realizes the mortal mistakes she has made as her weight swells to 600-lbs and her health crumbles.

After a difficult childhood with an abusive stepfather and drug-addicted mother, Sarah weighs over 600-lbs and is fighting for her life at only 24 years old.

Devastated by two miscarriages due to her weight, Schenee is desperate to start a family and stop relying on her husband, Freddie, to take care of her. Will weight loss surgery be able to fix her fertility issues as well as her marriage?

Jennifer and her daughter Marissa are stuck in a codependent relationship that has put both of their lives in jeopardy, with a combined weight of over 900-lbs. Can Jennifer regain control and save both of their lives before it's too late?

After a lifelong struggle with obesity, the three Perrio siblings travel to Houston in a last-chance journey to lose weight. Will they be able to break decades of unhealthy habits without fracturing as a family?

With the Perrios struggling with different stages of their weight loss journey, the revelation of a past tragedy explains their resistance to recovery. The siblings must now come together to overcome their fears and forge a path towards a healthy future.