John & Lonnie are two brothers from opposite ends of the spectrum; estranged for years, the brothers are brought together by a common need to lose weight while they still can.

Lindsey Witte had it all: a white picket fence, a loving husband, a great job. But now her food addiction is threatening to ruin everything. And as she embarks on a weight loss journey to save her life, is her husband a support or an addict himself?

Bethany has two daughters who live in fear of losing their mom to her food addiction. Once an addiction counselor, Bethany has gotten so big that she can no longer work. Now she risks losing her life, if Dr. Now can't help her curb her own addiction.

J.T. is almost 900lbs with a 100-lb lymphedema mass on his leg and a food addiction that is bound to kill him if he doesn't change. His girlfriend takes him to Houston, but when his behavior drives her away, J.T. is left with only Dr. Now to help.

When Travis got too big to walk down the aisle, he promised to give his wife a proper wedding one day. Since then he's only gained weight. Now, Dr. Now is Travis's only hope to lose weight and get the life he and his wife dreamed of having together.

When Travis gets too big to walk down the aisle, he promises his wife a proper wedding, leaving Dr. Now as Travis' only hope to lose weight and get the life he and his wife dreamed of having together.

Joyce needs home health care 24/7 and hasn't left the house in 3 years. But getting to Dr. Now in Houston is just the first step, and when he prescribes therapy where Joyce must revisit an unhappy past with her mom, it might be more than she can handle.

Shantel's brother Carlton lives downstairs but she hardly ever sees him because at 600+ lbs each, neither can do the stairs safely. Now to break free from a death spiral of codependent eating they need Dr. Now's help to reforge their sibling relationship.

Seana is 23 and nearly 700 lbs, living at her mom's house, depressed and anxious, her weight-gain threatens her livelihood. Dr Now can give her the tools she needs to live, but until she chooses life, no one can save Seana but Seana.

At 600 lbs, Ashley had to move home so her mom can help her care for not just herself but her newborn daughter. Now Ashley must overcome a lifetime's worth of unfortunate circumstances and get Dr. Now's help to find a way to go on living.

Tommy wants to lose weight so he can marry his fiancee and have the life he always dreamed of with her, but to break the cycle of pathological eating that left him nearly bed-bound, he'll have to face a piece of his past he has always kept secret.

The four best reasons for Coliesa to live are her daughters. But after a heart attack and losing the love of her life in a car crash, Coliesa eats non-stop to escape from reality, and unless she can stop that, the next heart attack will be fatal.

Dominic's life is falling apart due to his food addiction; over 600 pounds and living in a van with his brother, he decides to leave California for Texas, where only Dr. Now can help him learn to face his life challenges without using food to cope.

At 24 years old and over 600 lbs Megan lives at home with her mom who cooks for her since Megan can't do much on her own; Megan must travel to Houston to meet Dr. Now and change her eating habit or her life may end before it ever begins.

Ashley is 24 years old and lives alone; her only source of comfort is food and the relationships she has online; but not a single one of her profiles are real; Ashley learns that Dr. Now isn't someone that she can lie to unlike her online friends.

For 23 years Leneatha has worked as a pharmacy tech at a local hospital; now she has a young daughter to support but she's so big that it is hard to move; if Dr. Now can't help her to stop eating, losing her job could be the least of her worries.

In year 3, Erica is succeeding on her weight loss journey when romantic misfortune sends her spiraling backwards; Benji Bolton must reach his goal weight without the support of his brother David, after a disagreement leaves the brothers estranged.

Alicia's relationship with her boyfriend comes under the microscope in the second year of her weight loss journey; now in her fourth year, Pauline must beg her way back onto the program after quitting when her last weigh-in didn't go so well.

Dottie faces an unexpected challenge to her weight-loss when her husband's drinking problem becomes intolerable for her and her son; Cynthia starts to wonder if being there for her kids at her current weight is more important than losing more.

In order to keep pace with her daughter Charly's weight loss, Charity must do something she's never done: find a way to go it alone; try as she might, Teretha finds one too many obstacles in the way of continuing with Dr Nowzaradan's program.

Together weighing more than a ton, siblings Roshanda, Brandie and Clarence set out to lose weight as a family; the all-for-one approach may be hurting more than it helps when each of them shows signs of heading in the wrong direction after surgery.

If Steve Sr. thought getting weight-loss surgery for his sons would help bring them together, the third year of their weight-loss journey will prove him wrong, as Justin returns to Rhode Island with every intention of never speaking to Steven again.