Octavia has been bedbound for nearly a year when she decides to make the trip to Houston to get help from Dr. Now, but when it turns out that her best friend is also her worst enabler, Octavia will have to choose between old habits and a new life.

At over 700 pounds, Brianne undertakes a weight-loss journey to save her own life and faces an unexpected challenge to her fragile progress when her husband suffers a heart attack on a birthday she will never forget.

Robin and her brother Chris are both obese and already lost a sibling to obesity. They plan to visit Dr. Now together when Chris suffers a stroke and can't go. Luckily for Robin, Chris's son Garrett, already 600lbs at age 20, is game to join the journey.

A college graduate with a once-promising career, Justin has eaten his life away to the point of never leaving the house for anything but food. Now only the help of Dr. Now's weight-loss program can restore his hopes of living a happy, productive life.

Holly already has one failed weight loss surgery, so to succeed this time, she must do more than change her eating habits, she must address the childhood issues that continue to plague her.

Lacey ballooned up over 600 lbs on pizza and ice cream and knows Dr. Now is her best hope for success. She must now rally her divorced parents around her for support and find a way to modulate her moods that won't include binge-eating.

Brandon is a talented musician with a beautiful voice and a run-away weight problem. He wants more than to lose weight, he wants a career and he wants to take the next step with his girlfriend Taylor whom he risks losing if he can't make a change.

Maja moves to Houston to undertake a difficult weight-loss journey with the support of her boyfriend Christian. But when Christian decides he's had enough and leaves Maja high and dry, she will discover that the only person she can count on is herself.

Despite moving to Houston with the solid support network of her boyfriend Aaron and her cousin Jasmine, Tiffany finds it difficult to break the cycle of depressed eating when her two roommates don't join her diet and leave the house every day for work.

Born as 'Matthew', Destinee never felt like she fit in. Now, having come out as a 600 pound transgender woman, she likes her curves, but she will need to say goodbye to them if she wants to be approved to transition completely.

Jeanne lives in an unhygienic household with her mother and schizophrenic father. At well-over 600 lbs., Jeanne might never get weight-loss surgery as she runs into several obstacles, especially after an unexpected death in her family.

Since the death of his mother, Aaron has lived at home to care for his aging father. But due to his food addiction, Aaron has to heavily rely on his father for help instead. Now, Aaron must learn to care for himself to avoid eating himself to death.

Kelly is on the verge of immobility when she decides to make the trip to Houston to visit Dr. Now. Her journey gets off to a painful start when a long travel-day grows longer as Kelly gets stuck in a cab on her way from the clinic to the hospital.

When Annjeanette was 9, a campaign was established to send her to fat camp. She hated that her weight had become a source of public shame and she has struggled to overcome her food addiction. Now, she must change her habits to save her life.

When Angela's family is unable to accompany her on her weight-loss journey to Texas she is unsure what to do. At the last minute, she reaches out to an old flame, Eric, who still has love for her and is willing to make the trip.

A mother of 4, bed-bound for 2 years, Lashanta relies on her kids to keep her cleaned and fed. Her last chance to break the cycle of food addiction that's killing her is to join Dr. Now's program, but it will take a village just to get her out the door.

Cillas' food addiction is getting in the way of his ability to be there for his fiancee, Jessica, and her 3 daughters. If he doesn't lose weight soon, he knows he'll lose either his girls, or his life.

With severe lymphedema, Mercedes can barely stand and only cares for her 2 small children with the help of her extended family. Dr. Now can give her the tools to lose weight, but to succeed she must face the trauma inflicted by her late abusive father.

At over 600-lbs, Angie is trying to get to Houston to see Dr. Nowzaradan, in hope of getting weight loss surgery to save her life. But family conflict and a disagreements may stop her from being able to do what she needs before she even gets the chance.

A couple who love food decide to take on a healthier lifestyle and head to Houston to see Dr. Now. Their relationship is tested as they go on their journey.

Steven is healing from weight loss surgery and Justin decides to undergo the same operation. However, Justin reconsiders when his feelings towards his brother.sour.

Still 500 pounds and immobile a year after starting her weight loss program, Dr. Now see no other options for treatment for Janine.

Lee's anger issues continue to jeopardize his relationship with Rena and threatens to derail both of their weight loss journeys, while a major life event sends Sarah into a depression, and she must pull herself out of if she wants to keep losing weight.

In the 4th year of his weight loss journey, Sean struggles to get past the loss of his mother and live on his own. Dr. Now intervenes to control Sean's eating for a time, but if Sean can't learn to control himself, he will face the direst of consequences.

Liz has gone from being bedbound with lymphedemas on both legs, to standing and walking, but old fears are about to threaten her progress. And if Jenn and Marissa can't get along as mother and daughter to lose weight, they'll have to proceed apart.

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